Humanin

Preclinical

Anti-Aging & Skin

A mitochondrial-derived peptide with powerful cytoprotective effects that protects against age-related diseases and cellular stress.

Administration

Subcutaneous injection

Dosage Range

1-5 mg weekly (research dosing)

Mechanism of Action

Humanin binds to IGFBP-3 and BAX, inhibiting apoptosis and protecting cells from oxidative stress. It activates STAT3 signaling and reduces amyloid-beta toxicity, providing broad cytoprotective effects.

Clinical Benefits

Powerful cytoprotection

Reduces Alzheimer's pathology

Protects against oxidative stress

Supports cardiovascular health

Anti-aging at cellular level

Clinical Evidence

Discovered in 2001 from Alzheimer's patient brain tissue. Extensive preclinical evidence for neuroprotection, cardioprotection, and metabolic improvement. Circulating levels correlate with longevity in centenarian studies.

Side Effects

Injection site reaction

Mild nausea

Headache (rare)

Contraindications

Active cancer

Pregnancy

Autoimmune conditions

Related Peptides in Anti-Aging & Skin

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A copper peptide complex that stimulates collagen synthesis, promotes wound healing, and reverses gene expression associated with aging.

Epithalon

A synthetic tetrapeptide that activates telomerase, potentially extending cellular lifespan and slowing biological aging.

Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice. Peptide therapy should only be administered under the supervision of a qualified healthcare provider. Always consult your physician before starting any new treatment protocol.