Dihexa

Preclinical

Cognitive Enhancement

An angiotensin IV analog with extraordinary potency for cognitive enhancement, being 10 million times more potent than BDNF at promoting neuronal connections.

Administration

Oral/sublingual

Dosage Range

10-20 mg daily (sublingual)

Mechanism of Action

Dihexa activates hepatocyte growth factor (HGF)/c-Met signaling pathway, dramatically promoting synaptogenesis and dendritic spine formation. It crosses the blood-brain barrier and enhances cognitive function.

Clinical Benefits

Extraordinary cognitive enhancement

Promotes new neural connections

Potential Alzheimer's treatment

Enhances memory consolidation

Supports neuroplasticity

Clinical Evidence

Preclinical studies at Washington State University demonstrated remarkable cognitive enhancement in animal models. Shown to reverse cognitive deficits in models of dementia. Human trials pending.

Side Effects

Headache

Elevated blood pressure (monitor)

Anxiety at high doses

Contraindications

Uncontrolled hypertension

Active cancer

Pregnancy

Cardiovascular disease

Related Peptides in Cognitive Enhancement

Selank

A synthetic peptide analog of tuftsin with anxiolytic and nootropic properties that enhances cognitive function without sedation.

Semax

A synthetic ACTH analog that enhances cognitive function, provides neuroprotection, and supports brain recovery from injury.

Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice. Peptide therapy should only be administered under the supervision of a qualified healthcare provider. Always consult your physician before starting any new treatment protocol.